北京大学肿瘤医院研究员，博士生导师，中华医学会医学细胞生物学分会青年委员，入选首批博士后创新人才支持计划。长期从事生物医药与人工智能交叉领域研究，聚焦生物分子互作预测、肿瘤表观遗传调控机制及AI驱动的靶点发现与药物设计，采用“干湿结合+AI赋能”研究范式，致力于解析肿瘤发生及肿瘤免疫过程中的关键分子及其调控网络，探索新型靶向治疗策略与创新药物转化。

截止2025年，发表学术论文40余篇，总引用2960余次，其中以第一或通讯作者（含共同）发表论文21篇，代表性成果发表在Nature Machine Intelligence，STTT、Nature Communications、Cell Research等期刊，相关成果获2023年北京市自然科学二等奖。主持国家自然科学基金面上项目和青年项目，并参与多项科技部重点研发计划及国自然重大研究计划。 

代表性成果：

课题：

1. 国家自然科学基金, 面上项目, 32270640, 异染色质蛋白BAHD1参与表观遗传调控的分子结构机制及其相分离介导的功能研究, 2023/01- 2026/12，主持

2. 国家重点研发计划，2021YFF1201300，多模态大数据驱动的肿瘤智能诊疗靶标发现新技术研究，2022/01-2024/11，课题骨干，参与

3. 国家自然科学基金, 青年科学基金，31900862，YEATS家族蛋白GAS41参与肿瘤发生的结构和作用机制研究，2020/01-2022/12，主持

4. 中国博士后创新人才支持计划，BX201600088，癌症因子GAS41参与表观遗传调控的结构和分子机制研究，2016/07-2018/07，主持

代表性论著：

1. Xingang Peng#；Yipin Lei#；Peiyuan Feng；Lemei Jia；Jianzhu Ma；Dan Zhao*；Jianyang Zeng*；Characterizing the interaction conformation between T cell receptors and epitopes with deep learning, Nature Machine Intelligence, 2023, 5: 395-407

2. Yiyue Ge#；Tingzhong Tian#；Suling Huang#；Fangping Wan#；Jingxin Li#；Shuya Li；Xiaoting Wang；Hui Yang；Lixiang Hong；Nian Wu；Enming Yuan；Yunan Luo；Lili Cheng；Chengliang Hu；Yipin Lei；Hantao Shu；Xiaolong Feng；Ziyuan Jiang；Yunfu Wu；Ying Chi；Xiling Guo；Lunbiao Cui；Liang Xiao；Zeng Li；Chunhao Yang；Zehong Miao；Ligong Chen；Haitao Li；Hainian Zeng；Dan Zhao*；Fengcai Zhu*；Xiaokun Shen*；Jianyang Zeng*; An integrative drug repositioning framework discovered a potential therapeutic agent targeting COVID-19, Signal Transduction and Targeted Therapy, 2021, 6(1):165

3. Yaosen Min#；Ye Wei#；Peizhuo Wang#；Xiaoting Wang；Han Li；Nian Wu；Stefan Bauer；Shuxin Zheng；Yu Shi；Yingheng Wang；Ji Wu*；Dan Zhao*；Jianyang Zeng*；  From static to dynamic structures: Improving binding affinity prediction with graph-based deep learning, Advanced Science, 2024, 11(40):e2405404

4. Peizhuo Wang；Xiao Wen；Han Li；Peng Lang；Shuya Li；Yipin Lei；Hantao Shu； Lin Gao; Dan Zhao*；Jianyang Zeng*；Deciphering driver regulators of cell fate decisions from single-cell transcriptomics data with CEFCON, Nature Communications, 2023, 14(1):8459 (Editors’ Highlights)

5. Shuya Li；Tingzhong Tian；Ziting Zhang；Ziheng Zou；Dan Zhao*；Jianyang Zeng*； PocketAnchor:Learning structure-based pocket representations for protein-ligand interaction prediction, Cell Systems, 2023, 14(8):692-705（Cover Article）

6. Peiyuan Feng#; An Xiao#; Meng Fang; Fangping Wan; Shuya Li; Peng Lang; Dan Zhao*; Jianyang Zeng*; A novel machine learning based framework for modeling transcription elongation, PNAS, 2021, 118(6)

7. Dan Zhao#；Weifan Xu#；Xiaofan Zhang#；Xiaoting Wang；Enming Yuan；Yuanpeng Xiong；Shenyang Wu；Shuya Li；Nian Wu；Tingzhong Tian；Xiaolong Feng；Hantao Shu； Peng Lang；Xiaokun Shen；Haitao Li；Pilong Li* and Jianyang Zeng*；Understanding the phase separation characteristics of nucleocapsid protein provides a new therapeutic opportunity against SARS-CoV-2, Protein & Cell, 2021, 12(9):734-740

8. Dan Zhao; Haipeng Guan; Shuai Zhao; Wenyi Mi; Hong Wen; Tiemei Li; Yuanyuan Li; Yingming Zhao; C. David Allis; Or Gozani; Xiaobing Shi; Haitao Li; YEATS2 is a selective histone crotonylation reader, Cell Research, 2016, 26(5):629-632