医师，副研究员

专业擅长：

肿瘤核医学与分子影像精准评估，及核素靶向诊疗一体化技术应用。

在研课题：

国家自然科学基金青年项目，匹配-非小细胞肺癌肿瘤微环境中CD39+CD69+终末CD8+T细胞通过腺苷通路影响Th细胞功能的机制研究；

国家自然科学基金面上项目，匹配-靶向PD-L2高特异性单链抗体PET探针的构建、评价及其分子调控机制研究；

论文：

1. Zeng Z, Zhang Z, Xie Q, Tao J, Zhou W, Yuan C, Yang Z, Lu M, Yu J. Predicting 177Lu-DOTATATE therapy response through immune microenvironment parameters in gastroenteropancreatic neuroendocrine tumors (GEP-NETs). Eur J Nucl Med Mol Imaging. 2025 Aug 5. doi: 10.1007/s00259-025-07458-x. Epub ahead of print. PMID: 40762799.

2. Zeng Z, Li L, Tao J, Liu J, Li H, Qian X, Yang Z, Zhu H. [177Lu]Lu-labeled anti-claudin-18.2 antibody demonstrated radioimmunotherapy potential in gastric cancer mouse xenograft models. Eur J Nucl Med Mol Imaging. 2024 Apr;51(5):1221-1232. doi: 10.1007/s00259-023-06561-1. Epub 2023 Dec 8. PMID: 38062170.

3. Ziqing Zeng, Yong Zheng, Xieqiao Yan, Jinping Tao, Liqiang Li, Jin Ding, Xi’nan Sheng, Hua Zhu, Zhi Yang. On the shoulder of ADC: The development of 124I-IMMU-132, an iodine-124-labelled Trop-2-targeting molecular probe for micro-PET imaging. Biomedicine & Pharmacotherapy. Volume 178, 2024, 117151, ISSN 0753-3322.

4. Zeng Z, Du W, Yang F, Hui Z, Wang Y, Zhang P, Zhang X, Yu W, Ren X, Wei F. The spatial landscape of T cells in the microenvironment of stage III lung adenocarcinoma. J Pathol. 2024 Apr;262(4):517-528. doi: 10.1002/path.6254. Epub 2024 Feb 16. PMID: 38361487.

5. Zeng Z, Yang F, Wang Y, Zhao H, Wei F, Zhang P, Zhang X, Ren X. Significantly different immunoscores in lung adenocarcinoma and squamous cell carcinoma and a proposal for a new immune staging system. Oncoimmunology. 2020 Oct 7;9(1):1828538. doi: 10.1080/2162402X.2020.1828538. PMID: 33101777.