副教授、教育部新世纪优秀人才

北京医科大学本科及硕士研究生毕业(1991-1999)，美国马里兰大学博士毕业(2004)。北京大学基础医学院生物化学与分子生物学系副教授。2009年入选教育部“新世纪优秀人才支持计划”，2011年获北京大学绿叶生物医药杰出青年学者奖。以第一作者或责任作者身份发表研究性论文7篇，2013年受邀在《Annual Review of Physiology》发表题为“Estrogen and Cancer”的综述一篇。

电话：82801397 邮箱：liang_jing@hsc.pku.edu.cn

主要研究方向、成就

重点研究组蛋白修饰酶及识别因子在肿瘤发生发展和转移中的功能及分子机理。对转录抑制因子CDYL的系统性的功能学、进化发生、分子作用机制及细胞生物学功能进行了全方位探索。

承担课题

1. 国家自然科学基金面上项目：转录抑制因子CDYL 调控组蛋白甲基化遗传及巴豆酰化生成的研究(#31371301，2014-2017)

2. 科技部973项目课题：肿瘤治疗前后的异质性与抗药性演化机制(#2014CB542004，2014-2018)

3. 国家自然科学基金面上项目：CDYL介导H3K27甲基化酶EZH2的组蛋白识别及二者在乳腺癌发生中的机理研究(#30971637，2010-2012)

4. 教育部新世纪优秀人才支持计划：基因转录调控与肿瘤发生(# NCET-10-0184，2010-2012)

代表性论文(第一#或责任作者*)

1. Cai Qi, Shumeng Liu, Rui Qin, Yu Zhang, Guoqiang Wang, Yongfeng Shang, Yun Wang* and Jing Liang* (2014) Coordinated Regulation of Dendrite Arborization by Epigenetic Factors CDYL and EZH2. Journal of Neuroscience 34:4494-508

2. Yu Zhang, Jing Liang* and Qian Li* (2014) Coordinated regulation of retinoic acid signaling pathway by KDM5B and polycomb repressive complex 2. Journal of Cellular Biochemistry 115:1528-38

3. Xiaohan Yang, Jianguo Yang, Lei Li, Luyang Sun, Xia Yi, Xiao Han, Wenzhe Si, Ruorong Yan, Zhe Chen, GuojiaXie, Wanjin Li, Yongfeng Shang, and Jing Liang* (2014) PAAT, a novel ATPase and trans-regulator ofmitochondrial ABC transporters, is critically involved in the maintenance of mitochondrial homeostasis. FASEB Journal 28:4821-34

4. Jing Liang# and Yongfeng Shang* (2013) Estrogen and Cancer. Annual Review of Physiology 75:225-40

5. Yu Zhang, Xiaohan Yang, Bin Gui, GuojiaXie, Di Zhang, Yongfeng Shang, and Jing Liang* (2011) Corepressor Protein CDYL Functions as a Molecular Bridge between Polycomb Repressor Complex 2 and Repressive Chromatin Mark Trimethylated Histone Lysine 27. Journal of Biological Chemistry 286: 42414-25

6. Jing Liang#, Hua Zhang, Yu Zhang, Ying Zhang, and Yongfeng Shang* (2009) GAS, a novel glutamate-rich protein, interacts differentially with SRCs and is involved in oestrogen receptor function. EMBO Reports 10:51-7

7. Xin Li#, Jing Liang#, Haijing Yu, Bing Su, Chunjie Xiao, Yongfeng Shang, Wen Wang. Functional consequences of new exon acquisition in mammalian chromodomain Y-like (CDYL) genes. Trends in Genetics 23:427-431

8. Bin Shi#, Jing Liang#, Xiaohan Yang, Yan Wang, Youna Zhao, Huijian Wu, Luyang Sun, Ying Zhang, Yupeng Chen, Ruifang Li, Yu Zhang, Mei Hong, and Yongfeng Shang* (2007). Integration of estrogen and Wnt signaling circuits by the polycomb group protein EZH2 in breast cancer cells. Molecular and Cellular Biology 27:5105-19

9. Jing Liang#, Chaobo Yin, Howard Doong, Shengyun Fang, Corrine Peterhoff, Ralph A. Nixon and Mervyn J. Monteiro (2006) Characterization of erasin (UBXD2): a new ER protein that promotes ER-associated protein degradation. Journal of Cell Science 119: 4011-24